RAF Typhoon fighter aircraft have joined forces with French aircraft in a combined operation on an subterranean weapons facility in Syria used by the IS group, as stated by the British defence ministry.
The site, identified by reconnaissance, was assessed as housing weapons and explosive materials, the statement said, and was located in mountains just to the north of the historic site of Palmyra in the heart of Syria.
"Our fighter planes employed laser-guided Paveway IV weapons to strike a series of access tunnels leading to the site... early reports suggest the objective was successfully hit," the MoD said.
There was no sign of any civilian impact in the attack conducted Saturday night and every plane involved returned safely, the defence officials confirmed.
The British jets were assisted by a Voyager tanker plane.
Daesh - also known as the so-called Islamic State - established jihadist rule over significant areas in Iraq and Syria prior to its 2019 collapse.
"This strike underscores the UK's leading role, and determination to operate in unison with our allies, to eradicate any revival of Daesh and their dangerous and violent ideologies in the region," Britain's Defence Chief John Healey said.
RAF aircraft have conducted overwatch operations over Syrian airspace to "prevent any attempted resurgence" of IS following its defeat at the Baghuz confrontation in 2019, the MoD reported.
"I extend gratitude to all the members of the UK armed forces who took part in this mission for their skill and their bravery," the Defence Secretary commented. "Including them were thousands of British troops on duty over the holidays. This action, to eliminate dangerous terrorists who pose a risk to our way of life, demonstrates how British military are prepared to act, all year round, keeping Britain secure domestically and powerful internationally."
During December, the American forces conducted what it called a "large-scale strike" against IS targets in Syria, following an assault claimed the lives of two US servicemembers and a local interpreter in Palmyra.
The United Nations says Islamic State still maintains roughly 5-7 thousand fighters in Iraq and Syria.